Mailman School of Public Health
Population-based HIV/STD / infectious disease cohort, currently covering all consenting adults in 44 villages in rural Rakai District, southwestern Uganda. Cohort established in 1998. Annual door-to-door demographic, behavioral, and HIV/STD surveys.
Nested within the cohort are the following research activities: (1) population-based randomized, controlled trials of novel methods of HIV and STD control (trial of STD control for AIDS prevention, results published in Lancet and AIDS, 1999–2001; trial of presumptive STD treatment in pregnancy for improvement of maternal and infant health, published in the American Journal of Obstetrics and Gynecology, 2001; trial of male circumcision for HIV prevention (pending); (2) extensive operations research on improved HIV-prevention service delivery (condoms, health education, voluntary HIV testing and counseling, nevirapine provision for prevention of mother-to-child transmission, etc.); (3) descriptive studies of the effects of HIV viral load on HIV transmission (New England Journal of Medicine, 2000), and the association between HIV and other infections and reproductive outcomes including BV (NIAID RO1 in progress and Lancet 1997), HPV (JID 1999), HHV-8 (KSHV) (STD 2000); effects of HIV on fertility (Lancet 1997); demographic effects of HIV, etc. Over 45 peer-reviewed publications to date.
Project Leader/Principal Investigator
Heilbrunn Department of Population and Family Health
National Institute of Health (NIH)
Bill and Melinda Gates Foundation
Walter Reed Army Institute of Research
Uganda Ministry of Health