Malignant Transformation of Human Bronchial Epithelial Cells by Tobacco Nitrosamine and Radon Alpha Particles College of Physicians and Surgeons
To examine the cellular and molecular mechanisms of neoplastic transformation of immortalized human bronchial cells by the tobacco-specific nitrosamine NNK, either alone, or in combination with radon alpha particles. Causally linked gene(s) to the tumorigenic process will be identifed by comparing differentially expressed genes at various stages of the neoplastic process.
