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Mailman School of Public Health
The primary goal of this program is to obtain new knowledge and to train multidisciplinary pre- and post-doctoral students regarding the bioavailability of soil lead in humans and the bioavailability, health effects, and geochemistry of arsenic. The proposed work involves studies of bioavailability and/or geochemistry at four Superfund sites in the United States, two contaminated with lead and two with arsenic. It also encompasses epidemiologic and geochemistry studies of arsenic in drinking water in Bangladesh, which focus on carcinogenic, reproductive, and childhood effects of arsenic exposure. We also devote resources to the development of practical remediation strategies for arsenic in wastewater and drinking water.The program includes four biomedical research projects:(1) Bioavailability of Soil Lead and Arsenic in Humans (2) Genotoxic Mechanisms of Arsenic in Mammalian Cells (3) A Cohort Study of Health Effects of Arsenic Exposure in Bangladesh(4) Environmental Arsenic, Pregnancy, and Children's HealthThe biomedical research is directly related to that which occurs in three non-biomedical projects: (1) Arsenic Mobilization in Bangladesh Groundwater (2) Redistribution of Arsenic at Sites in New Jersey and Maine(3) Assessment and Remediation for Arsenic Enrichments in Groundwater.The projects are supported by three Research Support Core Labs: (1) Trace Metals (2) Geochemistry(3) HydrogeologyAn administrative core includes an information dissemination program and a government liaison and outreach program. Finally, a training core coordinates multidisciplinary education and interaction among pre- and post-doctoral trainees supported by this grant as well as other training grants.
Project Leader/Principal Investigator
Graziano, Joseph
Primary Contact
Graziano, Joseph
Locations
Bangladesh, United States of America
Department/Center
Department of Environmental Health Sciences
Funding Source
National Institute of Environmental Health Sciences (NIEHS)
Additional Researchers
Kazi Matin Ahmed Habib Ahsan (PI) Conrad Blum (PI) Paul Brandt-Rauf (PI) Steve Chillrud (PI) Mercy Davidson Pam Factor-Litvak Ittai Gavriela Annie Gerard Meredith Golden Tom Hei (PI) Sidney Hemming Geoffrey Howe Xinhua Liu Nancy Lo Iacono Jack Longley ,jl691@columbia.edu> Lee Marsi Xiaoguang Meng Nikolaos Nikolaidis Faruque Parvez Regina Santella Peter Schlosser H. James Simpson (PI) Vesna Slavkovich Ponisseril Somasundaran (PI) Michael Steckler Martin Stute (PI) Wei-Yann Tsai Alexander van Geen (PI) Roeloff Versteeg Gail Wasserman Yan Zheng (PI)
Collaborating Institutions
Mailman School of Public Health, Department of Epidemiology
Lamont-Doherty Earth Observatory
Ministry of Health, Bangladesh
Center for International Earth Sciences Information Network(CIESIN)
Henry Krumb School of Mines
College of Physicians and Surgeons
School of International and Public Affairs
University of Connecticut
Stevens Institute of Technology
Queens College, NY
National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh
Department of Geology, Dhaka University, Bangladesh
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