Project
A Phase I / II Randomised Controlled Study of OGT 918 in Niemann-Pick type C
College of Physicians and Surgeons
Niemann-Pick disease, type C (NPC), is a progressive neurodegenerative disorder in which abnormal intracellular lipid trafficking leads to accumulation of multiple lipids, including . . . More »
|  | Project Leader
Patterson, Marc
| | Location
United Kingdom
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Project
Application of Genetics and Genomics in Public Health in Developing Countries
Mailman School of Public Health
Research and Teaching About Ethical Applications of Genetics in health in Developing Countries . . . More »
| | Project Leader
Penchaszadeh, Victor B.
| | Location
Brazil
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Project
Assessing the Function of NEK2
College of Physicians and Surgeons
The long-term goal of the research effort is to elucidate the genetic program controlling the mitotic and meiotic divisions of the germ-line cells, with particular consideration of the evolutionary . . . More »
| | Project Leader
Wolgemuth, Debra
| | Location
Korea (south)
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Project
Cancer in the Jerusalem Perinatal Study
Mailman School of Public Health
The Jerusalem Perinatal Study is a population-based cohort of mothers, fathers and their 92,408 offspring born in 1964?76. Subsets of the cohort may be at risk for cancer through founder mutations . . . More »
| | Project Leader
Harlap, Susan
| | Location
Israel
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Project
Capacity Building and Training in Uses of Genetic and Genomics
Mailman School of Public Health
Capacity building and training in uses of genetics and genomics in the prevention of disease in developing countries, including the ethics of genetics research and genetic applications in the defense . . . More »
| | Project Leader
Penchaszadeh, Victor B.
| | Locations
Argentina, Brazil, Chile
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Project
Capacity Building in the Application of Genetics in the Prevention of Disease in Developing Countries
Mailman School of Public Health
Capacity building in the application of genetics in the prevention of disease in developing countries. . . . More »
| | Project Leader
Penchaszadeh, Victor B.
| | Locations
Argentina, Brazil
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Project
Cellular Immunity to HIV in Infants
Mailman School of Public Health
This is a study to investigate correlates of protective immunity to HIV among infants of HIV-infected mothers in South Africa. The study measures cell-mediated immune responses to HIV antigens in . . . More »
| | Project Leader
Kuhn, Louise
| | Location
South Africa
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Project
Clinical Gene Therapy Trial at the Pavia Medical Center
College of Physicians and Surgeons
We are providing MDR retriviral producer line for the following experiments: (1) transfer of the multidrug-resistence gene into human hematopoietic progenitors collected from bone marrow, peripheral . . . More »
| | Project Leader
Bank, Arthur
| | Location
Italy
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Project
Clinical Gene Therapy Trial for Patients with Lymphoma at University College London, UK
College of Physicians and Surgeons
We are providing the MDR-containing retroviral supernatants for the CD34+ cell transduction trial in patients with lymphoma. We are continuing experimentation in improving the efficiency of . . . More »
| | Project Leader
Bank, Arthur
| | Location
United Kingdom
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Project
Croatian Medical Journal
College of Physicians and Surgeons
Has been on publication's Advisory Board since the publication's inception.
More »
| | Project Leader
Erlenmeyer-Kimling, L
| | Location
Croatia
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Project
DNA Marker Study of Linkage to Schizophrenia: Program 1
College of Physicians and Surgeons
This study is concerned with the collection of families that have two or more members affected with schizophrenia. In each family, both affected and unaffected individuals receive diagnostic . . . More »
| | Project Leader
Erlenmeyer-Kimling, L
| | Location
Croatia
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Project
DNA Marker Study of Linkage to Schizophrenia: Program 2
College of Physicians and Surgeons, College of Physicians and Surgeons
The Croation-U.S. Study of genetic linkage in schizophrenia is a genetic-linkage and association study of families with schizophrenia, which makes use of the psychosis register established in Croatia . . . More »
| | Project Leader
Erlenmeyer-Kimling, L
| | Location
Croatia
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Project
Gene Mapping in the Finnish Population
College of Physicians and Surgeons
Consulting on statistical analysis of many simple and complex genetic disorders in isolated subpopulations of Finland. I also maintain and develop software for automated genetic analysis in their VMS . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Finland
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Project
Genes de Meiose / lLeur Implication dans Sterilite chez L'homme
College of Physicians and Surgeons
DNA is collected from infertile men who are otherwise healthy and who have normal Y-chromosomes, as detected by an extensive series of micro-deletion analyses. These samples are then sequenced to . . . More »
| | Project Leader
Wolgemuth, Debra
| | Location
France
|
Project
Gene Therapy in Cancer
College of Physicians and Surgeons
Using the multiple-drug resistance gene to provide hematopoietic stem cells with resistance to chemiotherpeutic agents. Using retroviral gene-transfer technique developed at Columbia. Patients with . . . More »
| | Project Leader
Bank, Arthur
| | Location
United Kingdom
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Project
Genetic Epidemiology of Aging Traits in Korean Populations
Mailman School of Public Health
The goal of this study is to examine how gene and environment interact to influence aging traits by studying Koreans who live in different parts of the world. For this pilot study, we are collecting . . . More »
| | Project Leader
Lee, Joseph H.
| | Location
Kazakhstan
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Project
Genetic Epidemiology of Alzheimer's Disease in Caribbean Hispanics
College of Physicians and Surgeons
We have recruited over three hundred families with one or more living relatives affected by Alzheimer's disease. Our goal is to identify genes that may contribute to Alzheimer's disease. We have held . . . More »
| | Project Leader
Mayeux, Richard
| | Location
Dominican Republic
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Project
Genetic Linkage Markers in Affective Disorders
College of Physicians and Surgeons
Search for linkage between DNA markers and affective disorders in a large series of Israeli pedigrees with high density of bipolar disorder. . . . More »
| | Project Leader
Baron, Miron
| | Location
Israel
|
Project
Genetic Modifications of Lipoprotein Lipase
College of Physicians and Surgeons
Studies to understand the functions of lipoprotein lipase, the rate-limiting enzyme for hydrolysis of plasma triglyceride. Genetically modified enzymes are studied in cells and mice. . . . More »
| | Project Leader
Goldberg, Ira
| | Location
Germany
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Project
Genetics of Simple Metabolic Diseases
College of Physicians and Surgeons
Statistical consulting in analysis of rare disorders of metabolism in the Czech Republic. . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Czech Republic
|
Project
Genetic Susceptibility to Arsenic-Induced Cancer
Mailman School of Public Health
A series of epidemiologic case-control and case-cohort studies nested within the Health Effects of Arsenic Longitudinal Study [HEALS] in Bangladesh examine the roles of inherent susceptibility to . . . More »
| | Project Leader
Ahsan, Habibul
| | Locations
Bangladesh, United States of America
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Project
Genome Database
College of Physicians and Surgeons
Senior chromosome editor for human chromosome 13.
More »
| | Project Leader
Warburton, Dorothy
| | |
Project
Glucose-Transporters (Type 1) Deficiency
College of Physicians and Surgeons
DFG (Deutsche Forschungemeindscnaft), Dr. Daryl DeVivo. Glucose, an essential fuel for the brain, is transported into the brain via a glucose-transporter protein, GLUT-1. In the glucose . . . More »
| | | | Location
Germany
|
Project
Human Gene Therapy Project and Thalassemia Research Projects
College of Physicians and Surgeons
We have collaborated with Dr. Magio and his colleagues for many years on research projects involving thalassemia: (1) the role of human globin gene promoters in the expression of hybrid genes in . . . More »
| | Project Leader
Bank, Arthur
| | Location
Italy
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Project
Huntington's Disease and Other Studies (Maracaibo)
College of Physicians and Surgeons
Nancy Wexler's inexhaustible energy, effective leadership, and dedication have played a central role in recent progress toward a cure for Huntington's disease. Involved in public policy, individual . . . More »
| | Project Leader
Wexler, Nancy
| | Location
Venezuela
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Project
Jerusalem Perinatal Cohort Schizophrenia Study
College of Physicians and Surgeons
Obstetric complications and other perinatal exposures are hypothesized to increase the risk for schizophrenia. However, studies in this area are usually limited by sample size and by their reliance . . . More »
| | Project Leader
Malaspina, Dolores
| | Location
Israel
|
Project
Korean Diaspora Project-Gene-Environment Interaction: China
College of Physicians and Surgeons
We are examining interactions between genetic and environmental factors as they influence quantitative trait variation by studying these traits in large families of overseas Koreans in Almaty and . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
China
|
Project
Korean Diaspora Project-Gene-Environment Interaction: Multinational
College of Physicians and Surgeons
We are examining interactions between genetic and environmental factors as they influence quantitative trait variation by studying these traits in large families of overseas Koreans in Almaty and . . . More »
| | Project Leader
Terwilliger, Joseph
| | Locations
Kazakhstan, China, Sweden, Korea (south)
|
Project
Korean Diaspora Project-Gene-Environment Interaction: Russian Federation (Europe)
College of Physicians and Surgeons
We are examining interactions between genetic and environmental factors as they influence quantitative trait variation by studying these traits in large families of overseas Koreans in Almaty and . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Russian Federation (Europe)
|
Project
Korean Diaspora Project-Gene-Environment Interaction: South Korea
College of Physicians and Surgeons
We are examining interactions between genetic and environmental factors as they influence quantitative trait variation by studying these traits in large families of overseas Koreans in Almaty and . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Korea (south)
|
Project
Korean Diaspora Project-Gene-Environment Interaction: Sweden
College of Physicians and Surgeons
We are examining interactions between genetic and environmental factors as they influence quantitative trait variation by studying these traits in large families of overseas Koreans in Almaty and . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Sweden
|
Project
Leadership Development in Biomedical Engineering
College of Physicians and Surgeons
Encourage undergraduate and graduate exchanges of biomedical-engineering students among participating institutions: Eindoven Technological University, The Netherlands; Hong Kong Polytechnic . . . More »
| | Project Leader
Mow, Van
| | Locations
Netherlands, Hong Kong, Japan, France, Switzerland
|
Project
Linkage Courses: Belgium
College of Physicians and Surgeons
Teaching of statistical-genetics methods and genetic-epidemiology methods for a week-long course. . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Belgium
|
Project
Linkage Courses: Italy
College of Physicians and Surgeons
Teaching of statistical genetics methods and genetic epidemiology methods as part of the master program in genetic epidemiology at the University of Pavia. . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Italy
|
Project
Linkage Courses: South Korea
College of Physicians and Surgeons
Teaching of statistical-genetics methods and genetic-epidemiology methods for a week-long course. . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Korea (south)
|
Project
Linkage Courses: Sweden
College of Physicians and Surgeons
Teaching of statistical-genetics methods and genetic-epidemiology methods for a week-long course. . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
Sweden
|
Project
Malignant Transformation of Human Bronchial Epithelial Cells by Tobacco Nitrosamine and Radon Alpha Particles
College of Physicians and Surgeons
To examine the cellular and molecular mechanisms of neoplastic transformation of immortalized human bronchial cells by the tobacco-specific nitrosamine NNK, either alone, or in combination with radon . . . More »
| | Project Leader
Hei, Tom K
| | Location
China
|
Project
Metabolic Bone Diseases in China
College of Physicians and Surgeons
This project is a far-ranging international collaboration between the Metabolic Bone Diseases Unit at Columbia-Presbyterian Medical Center and our counterparts in Beijing (PUMC), Shanghai (Second . . . More »
| | Project Leader
Bilezikian, John
| | Location
China
|
Project
Molecular Biomarks of Carcinogen Exposure
Mailman School of Public Health
This project has evaluated the utility of biomarkers based on mutations in oncogenes and tumor suppressor genes in individuals exposed to carcinogen vinyl chloride in France. . . . More »
| | Project Leader
Brandt-Rauf, Paul
| | Location
France
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Project
Molecular Genetics of Obesity and Type 2 Diabetes: France
College of Physicians and Surgeons
Current research activities include efforts to identify genes (and relevant allelic variants) related to obesity and/or type 2 diabetes in mice and humans. The lab has particular interest in the . . . More »
| | Project Leader
Leibel, Rudolph
| | Location
France
|
Project
Molecular Genetics of Obesity and Type 2 Diabetes: United Kingdom
College of Physicians and Surgeons
Current research activities include efforts to identify genes (and relevant allelic variants) related to obesity and/or type 2 diabetes in mice and humans. The lab has particular interest in the . . . More »
| | Project Leader
Leibel, Rudolph
| | Location
United Kingdom
|
Project
Molecular Mechanisms of Neural Induction
College of Physicians and Surgeons
A research program devoted to understanding the mechanisms of how the nervous system is established at the cellular and molecular level, using several model systems (Xenopus, chick, mouse) and . . . More »
| | Project Leader
Stern, Claudio
| | Location
United Kingdom
|
Project
Nuclear Envelope and Muscle Diseases: France
College of Physicians and Surgeons
The nuclear membranes and associated nuclear lamina network separate chromatin from the cytoplasmic compartment. Mutations in emerin, a transmembrane protein of the inner nuclear membrane, have been . . . More »
| | Project Leader
Worman, Howard
| | Location
France
|
Project
Nuclear Envelope and Muscle Diseases: Japan
College of Physicians and Surgeons
The purpose of the project is to elucidate the mechanisms linking mutations in the ubiquitously expressed lamins A and C to a dysfunction of skeletal and cardiac muscles. This project combines . . . More »
| | Project Leader
Worman, Howard
| | Location
Japan
|
Project
Nuclear Envelope and Muscle Diseases: Norway
College of Physicians and Surgeons
The goal of this project is to elucidate the mechanisms linking mutations in the ubiquitously expressed lamins A and C to a dysfunction of skeletal and cardiac muscles. This multidisciplinary project . . . More »
| | Project Leader
Worman, Howard
| | Location
Norway
|
Project
Search for Genes Involved in Intervertebral Disk Disease: Program 1
College of Physicians and Surgeons
Lower-back pain is often caused by intervertebral disk disease. In a recent paper, this disease has been shown to be associated with a polymorphism in a collagen gene. Researchers in Hong Kong are . . . More »
| | Project Leader
Ott, Jurg
| | Location
Hong Kong
|
Project
Search for Genes Involved in Intervertebral Disk Disease: Program 2
College of Physicians and Surgeons
Lower-back pain is often caused by intervertebral disk disease. In a recent paper, this disease has been shown to be associated with a polymorphism in a collagen gene. Researchers in Hong Kong are . . . More »
| | Project Leader
Ott, Jurg
| | Location
Hong Kong
|
Project
Structure and Function of Imprinted Gene Cluster on Chromosome 11p15/distal 7
College of Physicians and Surgeons
This is a collaborative grant involving four laboratories in four different countries to study the several aspects of genomic imprinting and imprinted genes. The emphasis is on the gene sequencing, . . . More »
| | Project Leader
Tycko, Benjamin
| | |
Project
The Function of the Mammalian Rad-9 Checkpoint Control Gene
College of Physicians and Surgeons
Investigating the function of human orthologenes at the fission yeast s. poumbe rad-9 checkpoint control gene. . . . More »
| | Project Leader
Lieberman, Howard
| | Location
Canada
|
Project
U.S.-Japan Cooperative Research Program in Carcinogenesis and Mutagenesis.
College of Physicians and Surgeons
Joint U.S.-Japan yearly workshops in mutagenesis and carcinogenesis and a scientist-exchange research program plus sharing of reagents and research materials. . . . More »
| | Project Leader
Weinstein, I
| | Location
Japan
|
Project
Wellcome Trust Summer Schools
College of Physicians and Surgeons
Teaching of statistical-genetics methods and genetic-epidemiology methods as part of the Wellcome Trust summer schools course on genetic analysis of complex traits. . . . More »
| | Project Leader
Terwilliger, Joseph
| | Location
United Kingdom
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